clarithromycin concentration dependent

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clarithromycin concentration dependent

Clarithromycin produced a similar concentration-dependent block with an IC50 of 45.7 +/- 1.1 microM and Hill Slope factor of 1.0 +/- 0.1. Erythromycin (25-250 ... , ,With clarithromycin, however, there is a clearly demonstrated concentration-dependent effect obtained with either a single or double administration. Dr. Mazzei and ... , MIC & Time- vs Concentration-Dependent Killing. Time course of systemic drug concentration following drug administration. MIC: Mimimal ...,The CERTs induced by clarithromycin, metronidazole, and tinidazole alone and in the combinations tested were concentration dependent, with no maximum ... ,Similar dose dependency has been observed with the 14-hydroxy metabolite (1). Thirty to 40% of an oral dose of clarithromycin is excreted unchanged or as an ... ,Similar dose dependency was noted in the pharmacokinetics of the 14(R)-hydroxy metabolite. Mean urinary excretion of clarithromycin and its 14(R)-hydroxy ... ,The pharmacokinetics of clarithromycin appeared to be dose dependent, with terminal disposition half-life ranging from 2.3 to 6.0 h and mean +/- standard ... ,Time-Dependent Killing: For instance, certain antibiotics, like beta-lactams (penicillins, cephalosporins, carbapenems, monobactams), clindamycin, macrolides (erythromycin, clarithromycin), oxazolidinones (linezolid), can be effective because of the exten, The time-dependent antibiotics exert optimal bactericidal effect when drug concentrations are maintained above the minimum inhibitory ...

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clarithromycin concentration dependent 相關參考資料
Characterization of the inhibitory effects of erythromycin and ...

Clarithromycin produced a similar concentration-dependent block with an IC50 of 45.7 +/- 1.1 microM and Hill Slope factor of 1.0 +/- 0.1. Erythromycin (25-250 ...

https://www.ncbi.nlm.nih.gov

Clarithromycin: pharmacokinetic and pharmacodynamic ...

https://www.ncbi.nlm.nih.gov

In Vitro Susceptibility and In Vivo Efficacy of Macrolides: A ...

With clarithromycin, however, there is a clearly demonstrated concentration-dependent effect obtained with either a single or double administration. Dr. Mazzei and ...

https://www.medscape.org

MIC & Time- vs Concentration-Dependent Killing - TMedWeb

MIC & Time- vs Concentration-Dependent Killing. Time course of systemic drug concentration following drug administration. MIC: Mimimal ...

http://tmedweb.tulane.edu

Pharmacodynamic Effects of Nitroimidazoles Alone and in ...

The CERTs induced by clarithromycin, metronidazole, and tinidazole alone and in the combinations tested were concentration dependent, with no maximum ...

https://www.ncbi.nlm.nih.gov

Pharmacokinetic properties of clarithromycin: A comparison ...

Similar dose dependency has been observed with the 14-hydroxy metabolite (1). Thirty to 40% of an oral dose of clarithromycin is excreted unchanged or as an ...

https://www.ncbi.nlm.nih.gov

Pharmacokinetics of clarithromycin, a new ... - NCBI - NIH

Similar dose dependency was noted in the pharmacokinetics of the 14(R)-hydroxy metabolite. Mean urinary excretion of clarithromycin and its 14(R)-hydroxy ...

https://www.ncbi.nlm.nih.gov

Pharmacokinetics of clarithromycin, a new macrolide ... - NCBI

The pharmacokinetics of clarithromycin appeared to be dose dependent, with terminal disposition half-life ranging from 2.3 to 6.0 h and mean +/- standard ...

https://www.ncbi.nlm.nih.gov

Time-Dependent vs. Concentration-Dependent Killing

Time-Dependent Killing: For instance, certain antibiotics, like beta-lactams (penicillins, cephalosporins, carbapenems, monobactams), clindamycin, macrolides (erythromycin, clarithromycin), oxazolidin...

http://www.antimicrobe.org

Which Antibiotics Are Time- or Concentration-Dependent?

The time-dependent antibiotics exert optimal bactericidal effect when drug concentrations are maintained above the minimum inhibitory ...

https://www.medscape.com