catenin apc
由 PJ Morin 著作 · 1997 · 被引用 5134 次 — Individuals who inherit APC mutations develop thousands of colorectal tumors, consistent with the tumor suppressor or “gatekeeping” role of APC protein in ... ,由 J Yang 著作 · 2006 · 被引用 262 次 — Our results suggest that APC regulates β-catenin phosphorylation and ubiquitination by distinct domains and by separate molecular mechanisms. ,由 TW Parker 著作 · 2020 · 被引用 99 次 — APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destruction. Following Wnt ligand presentation, this ... ,由 D Zhang 著作 · 2024 · 被引用 4 次 — Axin and APC as scaffold proteins undergo LLPS to form destruction complex condensates which recruit β-catenin, CK1a, and GSK3β to the droplets, ... ,由 M Chen 著作 · 2024 · 被引用 3 次 — In conclusion, APC/PIK3CA mutations and active β-catenin accumulation predict the efficacy of tankyrase inhibitors in CRC cells. Furthermore, ... ,由 MJ Hart 著作 · 1998 · 被引用 1120 次 — Axin acts as a scaffold upon which APC, β-catenin and GSK3β assemble to coordinate the regulation of β-catenin signaling. ,由 S Colnot 著作 · 2004 · 被引用 405 次 — Liver-Targeted Apc Ablation Activates β-Catenin Signaling and Quickly Induces Major Phenotypic Changes. C57BL/6N Apc+/lox mice were intercrossed to generate Apc ... ,由 BR Henderson 著作 · 2002 · 被引用 409 次 — APC and β-catenin display dynamic subcellular distributions. Their localization is influenced by nuclear-cytoplasmic transport, nuclear and membrane retention ... ,APC功能喪失是大腸直腸癌發病的早期事件。超過80%的大腸直腸癌病人帶有APC 功能喪失與β-catenin 在細胞核的累積，並造成TCF/LEF 調控的基因被活化。90%的大腸直腸癌病人 ...
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 catenin apc 相關參考資料
Activation of β-Catenin-Tcf Signaling in Colon Cancer by ...
由 PJ Morin 著作 · 1997 · 被引用 5134 次 — Individuals who inherit APC mutations develop thousands of colorectal tumors, consistent with the tumor suppressor or “gatekeeping” role of APC protein in ...... https://www.science.org Adenomatous Polyposis Coli (APC) Differentially ...
由 J Yang 著作 · 2006 · 被引用 262 次 — Our results suggest that APC regulates β-catenin phosphorylation and ubiquitination by distinct domains and by separate molecular mechanisms. https://www.sciencedirect.com APC controls Wnt-induced β-catenin destruction complex ...
由 TW Parker 著作 · 2020 · 被引用 99 次 — APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destruction. Following Wnt ligand presentation, this ... https://www.nature.com APC mutations disrupt β-catenin destruction complex ...
由 D Zhang 著作 · 2024 · 被引用 4 次 — Axin and APC as scaffold proteins undergo LLPS to form destruction complex condensates which recruit β-catenin, CK1a, and GSK3β to the droplets, ... https://link.springer.com APCPIK3CA mutations and β-catenin status predict ...
由 M Chen 著作 · 2024 · 被引用 3 次 — In conclusion, APC/PIK3CA mutations and active β-catenin accumulation predict the efficacy of tankyrase inhibitors in CRC cells. Furthermore, ... https://www.nature.com Downregulation of β-catenin by human Axin and its ...
由 MJ Hart 著作 · 1998 · 被引用 1120 次 — Axin acts as a scaffold upon which APC, β-catenin and GSK3β assemble to coordinate the regulation of β-catenin signaling. https://www.sciencedirect.com Liver-targeted disruption of Apc in mice activates β-catenin ...
由 S Colnot 著作 · 2004 · 被引用 405 次 — Liver-Targeted Apc Ablation Activates β-Catenin Signaling and Quickly Induces Major Phenotypic Changes. C57BL/6N Apc+/lox mice were intercrossed to generate Ap... https://www.pnas.org The ins and outs of APC and β-catenin nuclear transport
由 BR Henderson 著作 · 2002 · 被引用 409 次 — APC and β-catenin display dynamic subcellular distributions. Their localization is influenced by nuclear-cytoplasmic transport, nuclear and membrane retent... https://www.ncbi.nlm.nih.gov 不同APC基因狀態大腸直腸癌患者藥物治療之抗藥性機轉研究
APC功能喪失是大腸直腸癌發病的早期事件。超過80%的大腸直腸癌病人帶有APC 功能喪失與β-catenin 在細胞核的累積，並造成TCF/LEF 調控的基因被活化。90%的大腸直腸癌病人 ... https://hub.tmu.edu.tw |