b catenin cancer

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b catenin cancer

As β-catenin is the central player of the canonical Wnt signaling and is frequently mutated in cancers, it is the most attractive target for cancer ..., Uncontrolled expression of β-catenin is known to drive multiple types of cancers, including colon cancer, hepatocellular carcinoma and ..., ,Since its discovery as a protein associated with the cytoplasmic region of E-cadherin, beta-catenin has been shown to perform two apparently unrelated ... , Importantly, the inhibition of Wnt signaling occurred downstream of β-catenin, encouraging applications in treatment of cancers caused by APC ..., Mutations of canonical Wnt signaling pathway genes frequently occur in cancer and lead to abnormal accumulation of the key effector β-catenin ..., Colorectal cancers show evidence of Wnt signaling pathway activation ... Keywords: Wnt, beta-catenin, colorectal cancers, gamma secretase, ..., The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular functions such as stem cell regeneration and ..., INTRODUCTION. β-Catenin is a multifunctional protein with a central role in physiological homeostasis. Its aberrant high expression leads to various diseases including cancer. ... Upon Wnt activation or genetic mutations of Wnt components, β-catenin accu, The β-catenin destruction complex. Colorectal cancer (CRC) is the representative of human cancer caused by Wnt signaling hyperactivation.

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b catenin cancer 相關參考資料
A PROTAC peptide induces durable β-catenin degradation ...

As β-catenin is the central player of the canonical Wnt signaling and is frequently mutated in cancers, it is the most attractive target for cancer ...

https://www.nature.com

Allosteric inhibitor of β-catenin selectively targets oncogenic ...

Uncontrolled expression of β-catenin is known to drive multiple types of cancers, including colon cancer, hepatocellular carcinoma and ...

https://www.nature.com

Beta-catenin - Wikipedia

https://en.wikipedia.org

beta-catenin signaling and cancer - PubMed - NIH

Since its discovery as a protein associated with the cytoplasmic region of E-cadherin, beta-catenin has been shown to perform two apparently unrelated ...

https://pubmed.ncbi.nlm.nih.go

Cancer cell specific inhibition of Wntβ-catenin signaling by ...

Importantly, the inhibition of Wnt signaling occurred downstream of β-catenin, encouraging applications in treatment of cancers caused by APC ...

https://www.nature.com

Is β-Catenin a Druggable Target for Cancer Therapy?: Trends ...

Mutations of canonical Wnt signaling pathway genes frequently occur in cancer and lead to abnormal accumulation of the key effector β-catenin ...

https://www.cell.com

Targeting the Wntbeta-catenin Pathway in Cancer ... - NCBI

Colorectal cancers show evidence of Wnt signaling pathway activation ... Keywords: Wnt, beta-catenin, colorectal cancers, gamma secretase, ...

https://www.ncbi.nlm.nih.gov

Targeting the Wntbeta-catenin pathway in cancer ... - PubMed

The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular functions such as stem cell regeneration and ...

https://pubmed.ncbi.nlm.nih.go

The regulation of β-catenin activity and function in cancer - NCBI

INTRODUCTION. β-Catenin is a multifunctional protein with a central role in physiological homeostasis. Its aberrant high expression leads to various diseases including cancer. ... Upon Wnt activation...

https://www.ncbi.nlm.nih.gov

Wnt signaling in cancer: therapeutic targeting of Wnt signaling ...

The β-catenin destruction complex. Colorectal cancer (CRC) is the representative of human cancer caused by Wnt signaling hyperactivation.

https://www.nature.com