Ceftriaxone concentration dependent
2019年4月5日 — use a 12-hourly dosing regimen; i.e. ceftriaxone 1 g [child: 25 mg/kg up to ... Cmax = maximal or peak concentration; “concentration-dependent ... ,2019年7月5日 — Peak:MIC is the parameter to optimize for concentration-dependent antibiotics. Time>MIC is the parameter to ... Ceftriaxone, Klebsiella sp. ,AUC/MIC [area under the inhibitory time curve (AUIC)] was chosen as the pharmacodynamic parameter for this analysis since ceftriaxone is a time-dependent killer and high peak concentrations are not needed. ,2020年7月29日 — Ceftriaxone is a third-generation cephalosporin with 83-96% protein binding. [51] The protein binding of ceftriaxone has been shown to be dose dependent with saturation of binding sites at higher doses resulting in a higher unbound fraction ,The kinetics of ceftriaxone, a cephalosporin, was studied in six healthy subjects who received bolus injections of 150, 500, and 1500 mg intravenously in a ... ,Antimicrobial killing characteristics are dependent on both the concentration of ... cephalosporins (e.g., ceftriaxone, ceftazidime, cefepime), 50%-70% fT>MIC ... ,Adequate concentrations of beta-lactam antibiotics in cerebrospinal fluid (CSF) are ... confirming that ceftriaxone exhibits time-dependent bactericidal activity. ,Interstitial fluid drug concentrations are proportional to and in rapid equilibrium with blood and, therefore, the concentration of the antibiotic correlates with bacterial ... ,For example, the Vd of daptomycin and the beta-lactam ceftriaxone, which are highly ... The second group includes drugs that exhibit concentration-dependent ... ,The mean non-protein-bound or free fraction of ceftriaxone was 27% (range 1–59%). Protein binding was concentration dependent (Figure 2). In patients with normal renal function (n = 8), the mean free fraction was 23% (range 1–50%), and in those with abnor
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 Ceftriaxone concentration dependent 相關參考資料
Antimicrobial Dosing and Kill Characteristics • LITFL • CCC ID
2019年4月5日 — use a 12-hourly dosing regimen; i.e. ceftriaxone 1 g [child: 25 mg/kg up to ... Cmax = maximal or peak concentration; “concentration-dependent ... https://litfl.com Clinical Pharmacology of Antibiotics | American Society of ...
2019年7月5日 — Peak:MIC is the parameter to optimize for concentration-dependent antibiotics. Time>MIC is the parameter to ... Ceftriaxone, Klebsiella sp. https://cjasn.asnjournals.org Clinical use of ceftriaxone: a pharmacokinetic ... - PubMed
AUC/MIC [area under the inhibitory time curve (AUIC)] was chosen as the pharmacodynamic parameter for this analysis since ceftriaxone is a time-dependent killer and high peak concentrations are not ne... https://pubmed.ncbi.nlm.nih.go Clinical use of ceftriaxone: A pharmacokinetic ... - ResearchGate
2020年7月29日 — Ceftriaxone is a third-generation cephalosporin with 83-96% protein binding. [51] The protein binding of ceftriaxone has been shown to be dose dependent with saturation of binding sites ... https://www.researchgate.net Effects of concentration-dependent plasma protein binding on ...
The kinetics of ceftriaxone, a cephalosporin, was studied in six healthy subjects who received bolus injections of 150, 500, and 1500 mg intravenously in a ... https://pubmed.ncbi.nlm.nih.go OPTIMIZING ANTIMICROBIAL PHARMACODYNAMICS: A ...
Antimicrobial killing characteristics are dependent on both the concentration of ... cephalosporins (e.g., ceftriaxone, ceftazidime, cefepime), 50%-70% fT>MIC ... https://www.sciencedirect.com Pharmacodynamics and bactericidal activity of ceftriaxone ...
Adequate concentrations of beta-lactam antibiotics in cerebrospinal fluid (CSF) are ... confirming that ceftriaxone exhibits time-dependent bactericidal activity. https://aac.asm.org Pharmacodynamics of Antimicrobial Agents: Time-Dependent ...
Interstitial fluid drug concentrations are proportional to and in rapid equilibrium with blood and, therefore, the concentration of the antibiotic correlates with bacterial ... http://www.antimicrobe.org Pharmacokinetics and Pharmacodynamics of Antibacterial ...
For example, the Vd of daptomycin and the beta-lactam ceftriaxone, which are highly ... The second group includes drugs that exhibit concentration-dependent ... https://www.ncbi.nlm.nih.gov pharmacokinetics of once-daily dosing of ceftriaxone in ...
The mean non-protein-bound or free fraction of ceftriaxone was 27% (range 1–59%). Protein binding was concentration dependent (Figure 2). In patients with normal renal function (n = 8), the mean free ... https://academic.oup.com |